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Dementia: Page 2
Researchers to study media coverage of 'overdiagnosis' tests
By
LabPulse.com staff writers
Dr. Mary O'Keeffe from the University of Sydney and colleagues will investigate media coverage of the following five tests:
August 26, 2019
AAIC update: Where blood-based dementia tests stand in 2019
By
Emily Hayes
Among three studies of blood tests flagged by meeting organizers was a report from Dr. Akinori Nakamura, PhD, of the National Center for Geriatrics and Gerontology in Obu, Japan, and colleagues that biomarker composite derived from ratios of plasma levels of amyloid-related peptides -- amyloid-β precursor protein (APP)669-711/amyloid-β (Aβ)1-42 and Aβ1-40/Aβ1-42 -- and tested with mass spectrometry were significantly correlated with results for beta amyloid as measured with PET scans. The study included 201 samples from patients seen in three Japanese centers, including patients with Alzheimer's disease, mild cognitive impairment, and non-Alzheimer's dementia.
July 15, 2019
Cerebrospinal fluid test helps pinpoint dementia disorders
By
Emily Hayes
The meta-analysis of studies involving about 10,000 people with neurological disorders showed that neurofilament light protein as measured with a commercially available immunoassay was elevated for people with neurological and psychiatric conditions. Results were broadly similar; however, frontotemporal dementia and HIV-related cognitive decline were differentiated from other dementias, and Parkinson's disease was differentiated from atypical parkinsonian conditions.
June 17, 2019
High cholesterol offers clues in early-onset Alzheimer's disease
By
Emily Hayes
The study of 2,125 people, including those with early-onset Alzheimer's disease and controls, found higher mean low-density lipoprotein cholesterol (LDL-C) in a subset of patients with early-onset disease, a type of dementia that strikes before the age of 65.
May 29, 2019
Newly defined dementia disease | Blood-based biomarker for CJD | Metabolic pathway screening in children
By
Emily Hayes
Dear LabPulse Member,
May 6, 2019
NIH study outlines pathology of newly defined dementia disorder
By
Emily Hayes
Called limbic-predominant age-related TDP-43 encephalopathy (LATE), the condition is characterized by misfolded TDP-43, a protein involved in the regulation of gene expression in the brain, and is associated with a decline in cognitive function.
April 29, 2019
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