Will Morton

Pathology and AI
Pathologists detect microplastics in human brain tissue
Pathologists have detected microplastics in the olfactory bulb brain tissues of eight deceased individuals in Sao Paulo, highlighting the need for further research about their effects on human health, reports a study published in JAMA Network Open.
September 25, 2024
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Artificial Intelligence
AI model shows promise detecting COVID-19 in low-resource settings
An artificial intelligence (AI) model shows promise for diagnosing COVID-19 in low-resource settings with severe shortages of medical experts, including in many African regions, according to a study published November 11 in Scientific Reports.
November 14, 2023
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Molecular Diagnostics
Does Tc-99m SPECT damage DNA?
In a pilot study, researchers studied the effect of ionizing radiation on patients who underwent MPI exams, also known as nuclear stress tests. They used a comet assay, a standard lab test for detecting DNA damage in cells, to analyze patient blood samples before and after they underwent imaging, with results suggesting a small yet likely irrelevant amount of damage.
September 19, 2022
2022 09 19 22 30 6972 2022 09 20 Spect Comet 20220919220954
Pathology, histology
Transgender hormone therapy can change lab test levels
Researchers led by Dr. Matthew Krasowski, PhD, of the University of Iowa Hospitals and Clinics, recruited healthy transgender and nonbinary individuals from clinics specializing in transgender medical care who had been prescribed either estradiol (n = 93) or testosterone (n = 82) for at least 12 months.
May 18, 2022
2019 08 05 17 59 6641 Aacc 2019 400
Alzheimer's
Does race affect interpretation of Alzheimer's disease tests?
An international team led by researchers at Washington University School of Medicine in St. Louis, MO, compared three experimental blood tests and a commercially available Alzheimer's disease test they developed in previous work (PrecivityAD, C2N Diagnostics) in 76 pairs of Black and non-Hispanic white participants.
April 21, 2022
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Federal Legislation
AACC criticizes FDA over warning on prenatal genetic tests
NIPTs can determine the risk of a fetus having certain genetic abnormalities, which could result in a child being born with a serious health condition. However, since they are not diagnostic tests, they cannot confirm or rule out a suspected genetic abnormality, the FDA said.
April 21, 2022
2021 09 27 23 11 0968 Aacc 2021 400
Alzheimer's
Spinal fluid tests may aid PET scans of Alzheimer's disease
A Swiss group led by senior author Michael Schöll, PhD, of the University Gothenburg investigated whether fluid and blood biomarkers that indicate Alzheimer's disease could predict the accumulation of neurofibrillary tau tangles seen on PET scans in patients diagnosed with the disease. They found the lab tests performed well enough to help select patients for PET imaging studies evaluating new treatments.Associations of baseline beta-amyloid PET and baseline phosphorylated tau-181 (p-tau181) with F-18 flortaucipir (FTP) Standardized uptake value ratio (SUVR) annualized change for (A) cognitively unimpaired and (B) cognitively impaired individuals. Image courtesy of Alzheimer's & Dementia: The Journal of the Alzheimer's Association.Associations of baseline beta-amyloid PET and baseline phosphorylated tau-181 (p-tau181) with F-18 flortaucipir (FTP) Standardized uptake value ratio (SUVR) annualized change for (A) cognitively unimpaired and (B) cognitively impaired individuals. Brain surface renderings depict Pearson correlation coefficients adjusted for age and sex (r) representing the strength of the association between the different biomarkers and F-18 flortaucipir SUVR change in each brain region. The right upper panel represents age- and sex-adjusted Pearson correlation coefficients (r), along with p-values, for the association between the biomarkers and F-18 flortaucipir SUVR change in the Alzheimer's disease meta-region of interest (ROI). The root mean squared error (RMSE) for the prediction of F-18 flortaucipir SUVR change by a linear model with the biomarker as predictor and age and sex as covariates. RMSE was estimated using leave-one-out cross-validation. Voxel-wise statistical maps were thresholded using more lenient cluster-forming thresholds of p < 0.05 (uncorrected) at the voxel level and further thresholded at the cluster level by restricting results to clusters with a number of voxels higher than the expected number of voxels as predicted using random field theory. Image courtesy of Alzheimer's & Dementia: The Journal of the Alzheimer's Association.
March 3, 2022
2022 03 02 20 27 6315 2022 03 04 Tau Biomarkers 400
Consumer
CMS will cover free over-the-counter COVID-19 tests
No date has been established, yet CMS said by early spring Medicare beneficiaries will be able to access up to eight over-the-counter COVID-19 tests per month for free at local pharmacies and other participating facilities. The policy applies to tests cleared by the U.S. Food and Drug Administration (FDA).
February 2, 2022
2020 03 13 20 59 0533 White House 400
Infectious
Neurodegenerative markers found in COVID-19 patients
Researchers at New York University (NYU) analyzed the serum of 251 hospitalized COVID-19 patients without a history of dementia, in particular looking for neurodegenerative markers. These included total tau (t-tau), phosphorylated tau-181 (p-tau181), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), ubiquitin carboxy-terminal hydrolase L1 (UCHL1), and beta-amyloid (Aβ40,42).
January 12, 2022
2020 03 31 23 03 5810 Brain Dementia Leaves 400
COVID-19
AI model identifies SARS-CoV-2 from blood tests, chest x-rays
Chinese researchers in Hong Kong designed a machine-learning model using blood tests taken during the first and second wave of infection since the start of the COVID-19 outbreak in April 2020. They found when combined with a radiologist's interpretation of x-rays, the model achieved a very high sensitivity in detecting COVID-19 infections.
July 15, 2021
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Mergers & Acquisitions
$16.5B CDMO deal unhindered by role in broader pharma supply chain
Novo Holdings greenlighted by European Commission to take control of U.S.-based CDMO.
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Business Insights
Texas lab owner accused of $79M RPP fraud scheme
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FDA Warning Letter
FDA sounds bacteria alarms over CGMP violations in Maine
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Research and Development
Revvity broadens work in newborn testing for NHS England
Body composition in patients treated with Ozempic
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Body composition in patients treated with Ozempic
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$16.5B CDMO deal unhindered by role in broader pharma supply chain
By Liz Carey
Novo Holdings greenlighted by European Commission to take control of U.S.-based CDMO.
December 11, 2024
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Texas lab owner accused of $79M RPP fraud scheme
By LabPulse.com staff writers
The DOJ implicated a Texas clinical laboratory owner and operator in respiratory pathogen panel testing fraud scheme.
November 25, 2024
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FDA sounds bacteria alarms over CGMP violations in Maine
By Liz Carey
Tom's troubles highlight the importance of being inspection-ready.
November 21, 2024
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Revvity broadens work in newborn testing for NHS England
By LabPulse.com staff writers
Revvity, formerly PerkinElmer, will expand its work with Genomics England to continue the Generation Project.
November 20, 2024
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Roche gets CE Mark for ovarian cancer CDx test
By LabPulse.com staff writers
Roche has received the CE Mark under the European Union's In Vitro Diagnostic Regulation for its companion diagnostic (CDx) test, which is designed to aid in identifying ovarian cancer patients eligible for targeted treatment with Abbvie's Elahere.
November 19, 2024
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AMP reviews pitfalls of NGS testing for SARS-CoV-2
By Liz Carey
Document offers key pre-analytical, analytical, and post-analytical considerations to help improve NGS-based surveillance programs.
November 15, 2024
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FDA fall IVD roundtable avoids LDT questions
By Liz Carey
In addition, CAP LDT webinar offers beginning guide for phase one compliance.
November 12, 2024
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Lucy Letby murder case flags immunoassays as unreliable for medical evidence
By Liz Carey
At least one pathologist has said it was wrong for scientists representing Liverpool Clinical Laboratories to insist insulin poisoning was the only explanation in a series of high-profile newborn deaths in the U.K., The Telegraph reported.
October 28, 2024
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Digital pathology rollouts race for proof-of-concept at national level
By Liz Carey
U.K. invests in clinical trial security while Australia's health minister issues powerful ultimatum.
October 29, 2024
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Caris Life Sciences embarks on 10K-sample breast cancer biomarker analysis project
By LabPulse.com staff writers
Caris will perform comprehensive molecular characterization of TAILORx tissue samples.
October 25, 2024
Dna Sequence (1)
ASCLS seeks support for med lab personnel act
By LabPulse.com staff writers
The proposed legislation includes loan repayment provisions and requires $25 million in the first year.
October 25, 2024
Washington Dc Capitol
Pathology groups' antitrust legal fight heats up
By LabPulse.com staff writers
A lawsuit in which Iowa pathologists are suing their former colleagues is escalating, with one side accusing the other of attempting to maintain a monopoly at the expense of patients.
October 24, 2024
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