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30-year-old woman with semaglutide use. Patient had stopped semaglutide use 36 days prior to post-semaglutide scan. Patient's weight was 148 kg on pre-semaglutide scan and 176 kg on post-semaglutide scan. Patient was thus assigned to weight-gain group. (A) Coronal maximum-intensity projection (MIP) image from pre-semaglutide scan shows organ segmentations. (B) Axial image from pre-semaglutide scan at L3 level shows color-coded tissue segmentations. (C) Coronal MIP image from post-semaglutide scan shows organ segmentations. (D) Axial image from post-semaglutide scan at L3 level shows color-coded tissue segmentations. Segmented visceral adipose tissue (VAT) is colored yellow, subcutaneous adipose tissue (SAT) is colored blue, skeletal muscle is colored red, liver is colored red, and spleen (not evaluated in present investigation) is colored orange. On pre- and post-semaglutide scans, VAT area was 358.5 cm2 and 412.1 cm2, muscle area was 186.8 cm2 and 225.2 cm2, muscle attenuation was -5.2 HU and -11.0 HU, liver volume was 2,579 and 3,851 mL, and liver attenuation was 77.8 HU and 59.2 HU, respectively. Images and caption courtesy of the American Journal of Roentgenology.
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