Research & Development
Labcorp NfL test confirms neurodegenerative disease
The neurofilament light chain (NfL) blood test will allow doctors to identify and verify signs of neurodegenerative disease, enabling physicians to provide a more effective and efficient path to diagnosis and treatment for patients, the firm said.
July 12, 2022
Shimadzu launches amyloid mass spectrometry service
The new approach predicts abnormal amyloid-beta concentration, which can be an indicator of amyloid pathology in the brain, the firm said.
July 10, 2022
New biomarker could detect early Alzheimer’s before symptoms
In addition, the findings have some implications for taking brain-boosting dietary supplements that contain the amino acid serine. The key compound responsible for producing serine in the body is PHGDH. The scientists reported that PHGDH mRNA and protein levels had increased in the brains of two mouse models of Alzheimer's disease or tauopathy.
May 4, 2022
FDA grants approval for Fujirebio assay for Alzheimer's plaques
The FDA granted clearance under its breakthrough device pathway to Fujirebio's Lumipulse G β-Amyloid Ratio (1-42/1-40) test, which is designed to measure the ratio of β-amyloid 1-42 and β-amyloid 1-40. These are proteins that can accumulate and form plaques in the brain; concentrations of these proteins can be detected in cerebral spinal fluid (CSF).
May 3, 2022
Insightec to launch new trials of Exablate Neuro
One study will evaluate the use of Exablate Neuro to treat patients with primary non-small cell lung cancer that has metastasized to the brain in conjunction with Keytruda, a humanized antibody immunotherapy. Exablate Neuro could be used to open up the blood-brain barrier to make immunotherapy agents like Keytruda more effective.
March 9, 2022
Spinal fluid tests may aid PET scans of Alzheimer's disease
A Swiss group led by senior author Michael Schöll, PhD, of the University Gothenburg investigated whether fluid and blood biomarkers that indicate Alzheimer's disease could predict the accumulation of neurofibrillary tau tangles seen on PET scans in patients diagnosed with the disease. They found the lab tests performed well enough to help select patients for PET imaging studies evaluating new treatments.Associations of baseline beta-amyloid PET and baseline phosphorylated tau-181 (p-tau181) with F-18 flortaucipir (FTP) Standardized uptake value ratio (SUVR) annualized change for (A) cognitively unimpaired and (B) cognitively impaired individuals. Image courtesy of Alzheimer's & Dementia: The Journal of the Alzheimer's Association.Associations of baseline beta-amyloid PET and baseline phosphorylated tau-181 (p-tau181) with F-18 flortaucipir (FTP) Standardized uptake value ratio (SUVR) annualized change for (A) cognitively unimpaired and (B) cognitively impaired individuals. Brain surface renderings depict Pearson correlation coefficients adjusted for age and sex (r) representing the strength of the association between the different biomarkers and F-18 flortaucipir SUVR change in each brain region. The right upper panel represents age- and sex-adjusted Pearson correlation coefficients (r), along with p-values, for the association between the biomarkers and F-18 flortaucipir SUVR change in the Alzheimer's disease meta-region of interest (ROI). The root mean squared error (RMSE) for the prediction of F-18 flortaucipir SUVR change by a linear model with the biomarker as predictor and age and sex as covariates. RMSE was estimated using leave-one-out cross-validation. Voxel-wise statistical maps were thresholded using more lenient cluster-forming thresholds of p < 0.05 (uncorrected) at the voxel level and further thresholded at the cluster level by restricting results to clusters with a number of voxels higher than the expected number of voxels as predicted using random field theory. Image courtesy of Alzheimer's & Dementia: The Journal of the Alzheimer's Association.
March 3, 2022
Genetic causes identified for three rare diseases
Researchers in study validate test to identify newborns with homocystinuria, a rare inherited disease
FDA reissues EUA for Janssen COVID-19 vaccine, includes warning about risks of myocarditis, pericarditis
National hepatitis C elimination program represents an historic opportunity, according to White House
Netherlands researchers combine CRISPR, bioluminescence in proof-of-concept infectious disease test
Duke University researchers discover biomarkers may identify early pancreatic cancer risk
NeuroVision receives funding to develop dementia blood test
The Sacramento, CA-based company will develop an "ultramultiplex assay" to measure multiple blood biomarkers that are associated with the development of dementia, it said. Additionally, the project will further NeuroVision's work on a proprietary blood assay that appears to mirror beta-amyloid protein load in the brain, the company noted.
August 23, 2021
BrainChip, NaNose laud progress in breath sample COVID-19 test
The test incorporates NaNose Medical's sensor array to collect data and BrainChip's Akida artificial intelligence chip to perform the diagnosis, according to the two firms. NaNose's sensory array is based on technology developed at Technion Israel Institute of Technology in Haifa, and has similar sensitivity to minute quantities of volatile organic compounds (VOCs) as a dog's nose.
February 24, 2021
AI-based test diagnoses dental infection-related brain abscess
The algorithm-based pathogenic sequencing technique, which provides quicker, more precise results than traditional lab bacterial cultures, showed that several types of bacteria that can colonize the oral cavity were found in the 53-year-old woman's brain and spinal cord fluid. She was diagnosed with ventricular and spinal canal empyema, which is rarely seen today due to medical advances.
August 20, 2020
FDA approves Avid's PET agent for tau pathology imaging
Tauvid is indicated for adult patients with cognitive impairment who are being evaluated for Alzheimer's disease. The PET radiopharmaceutical helps clinicians estimate the density and distribution of tau neurofibrillary tangles in the brain, which are a marker of Alzheimer's disease.
May 28, 2020
Gene biomarker shows promise as alternative early Alzheimer's blood test
The group evaluated extracellular RNA (exRNA) in plasma samples from 35 study participants who had confirmed Alzheimer's disease based on postmortem pathological brain examinations and who had been followed for 15 years prior to death. Of the total, nine had not been symptomatic and served as controls.
March 31, 2020
Blood samples, PET imaging link brain injuries to chronic encephalopathy
Researchers observed elevated levels of tau tangles and a certain blood chemical associated with traumatic brain injury (TBI), both of which could indicate current or future acute brain degeneration and possible progression to CTE as a result of brain injury from an improvised explosive device (IED).
February 26, 2020
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