Joseph Constance

COVID-19
Study of unfolding pandemic saw shift in symptoms, reductions in vaccines protection
According to the study, racial and sociodemographic disparities persisted in the third year of SARS-CoV-2 circulation and were present in rhinovirus infection.
December 9, 2022
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Prostate Cancer
Higher PSA screening rates associated with less metastatic prostate cancer
Investigators undertook a retrospective cohort study of patients to determine whether facility-level variations in PSA screening rates could be associated with subsequent facility-level metastatic prostate cancer incidence.
October 25, 2022
Mri Prostate
Sequencing
University of Pittsburgh NGS test shows high sensitivity in pancreatic cyst study
By sequencing 22 pancreatic cyst-associated genes, the PancreaSeq test distinguished benign cysts from those that could become cancerous.
October 6, 2022
Sequencing Dna Rna Social
Immune System Diseases
CRISPR may enable rapid, sensitive test for COVID-19
The device has the potential for use as a diagnostic test at the point of care (POC), according to its developers.
September 26, 2022
2022 09 23 14 44 4203 Crispr Tiles 400
Coronary Artery Disease
Polygenic score predicts risk of sudden cardiac death
In the study, published by researchers at Cedars-Sinai Medical Center in Los Angeles and collaborators elsewhere, patients with coronary artery disease but without severely impaired heart function received the highest polygenic risk score, indicating a 77% increased risk for sudden cardiac death.
August 28, 2022
2020 06 09 23 55 3449 Heart Attack Disease 3 D 400
Arrhythmia
In study, genetic testing catches missed cardiac diagnoses
Researchers at Northwestern University and colleagues reported that in their cohort study of 4,782 patients with a suspected genetic cardiomyopathy or arrhythmia, the combined testing approach captured nearly 11% of patients whose diagnosis would have been missed if genetic testing had been limited to a specific suspected disease.
August 24, 2022
2022 08 25 13 55 6515 Heart Health Stethoscope 400
Liver Cancer
Biomarker assay may speed primary liver cancer detection
While EVs are released by normal cells, they are released to a greater extent by tumor cells and cells within a tumor microenvironment. Investigators at the University of California at Los Angeles (UCLA) and collaborators elsewhere have developed a streamlined surface protein assay (HCC EV SPA) capable of analyzing and quantifying eight subpopulations of HCC EVs.
August 15, 2022
2021 06 08 21 44 7484 Cancer Cell Yellow 400
Sequencing
ACP paper outlines position on genetic testing
The authors noted that tests for specific genetic variants, polygenic risk scores, multicancer early detection tests using cell-free DNA, and whole-genome sequencing are among the emerging approaches for testing.
August 9, 2022
2019 04 17 00 53 3368 Dna Sequence 400
COVID-19
Researchers report on improved SARS-CoV-2 neutralization assay
In a study published recently in Nature Communications, the developers reported reconfiguring an earlier serological assay that they had developed based on a tri-part split-NanoLuc, a novel bioluminescence platform, to detect antibodies that bind to the SARS-CoV-2 spike protein.
July 17, 2022
2021 07 13 19 48 5862 Sars Co V 2 Ace2 Binding 400
Infectious
Pharmacogenomic testing for better depression treatment
In the study, the patients being treated for major depressive disorder (MDD) who received pharmacogenomics testing also experienced better depression outcomes soon after they were tested.
July 13, 2022
2022 07 14 15 26 8104 Mental Health Depression 400
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Top Stories
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Mergers & Acquisitions
$16.5B CDMO deal unhindered by role in broader pharma supply chain
Novo Holdings greenlighted by European Commission to take control of U.S.-based CDMO.
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Business Insights
Texas lab owner accused of $79M RPP fraud scheme
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FDA Warning Letter
FDA sounds bacteria alarms over CGMP violations in Maine
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Research and Development
Revvity broadens work in newborn testing for NHS England
Body composition in patients treated with Ozempic
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Body composition in patients treated with Ozempic
More in Home
$16.5B CDMO deal unhindered by role in broader pharma supply chain
By Liz Carey
Novo Holdings greenlighted by European Commission to take control of U.S.-based CDMO.
December 11, 2024
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Texas lab owner accused of $79M RPP fraud scheme
By LabPulse.com staff writers
The DOJ implicated a Texas clinical laboratory owner and operator in respiratory pathogen panel testing fraud scheme.
November 25, 2024
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FDA sounds bacteria alarms over CGMP violations in Maine
By Liz Carey
Tom's troubles highlight the importance of being inspection-ready.
November 21, 2024
Fda Logo V2 Social
Revvity broadens work in newborn testing for NHS England
By LabPulse.com staff writers
Revvity, formerly PerkinElmer, will expand its work with Genomics England to continue the Generation Project.
November 20, 2024
Baby Infant Mom Closeup Social
Roche gets CE Mark for ovarian cancer CDx test
By LabPulse.com staff writers
Roche has received the CE Mark under the European Union's In Vitro Diagnostic Regulation for its companion diagnostic (CDx) test, which is designed to aid in identifying ovarian cancer patients eligible for targeted treatment with Abbvie's Elahere.
November 19, 2024
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AMP reviews pitfalls of NGS testing for SARS-CoV-2
By Liz Carey
Document offers key pre-analytical, analytical, and post-analytical considerations to help improve NGS-based surveillance programs.
November 15, 2024
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FDA fall IVD roundtable avoids LDT questions
By Liz Carey
In addition, CAP LDT webinar offers beginning guide for phase one compliance.
November 12, 2024
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Lucy Letby murder case flags immunoassays as unreliable for medical evidence
By Liz Carey
At least one pathologist has said it was wrong for scientists representing Liverpool Clinical Laboratories to insist insulin poisoning was the only explanation in a series of high-profile newborn deaths in the U.K., The Telegraph reported.
October 28, 2024
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Digital pathology rollouts race for proof-of-concept at national level
By Liz Carey
U.K. invests in clinical trial security while Australia's health minister issues powerful ultimatum.
October 29, 2024
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Caris Life Sciences embarks on 10K-sample breast cancer biomarker analysis project
By LabPulse.com staff writers
Caris will perform comprehensive molecular characterization of TAILORx tissue samples.
October 25, 2024
Dna Sequence (1)
ASCLS seeks support for med lab personnel act
By LabPulse.com staff writers
The proposed legislation includes loan repayment provisions and requires $25 million in the first year.
October 25, 2024
Washington Dc Capitol
Pathology groups' antitrust legal fight heats up
By LabPulse.com staff writers
A lawsuit in which Iowa pathologists are suing their former colleagues is escalating, with one side accusing the other of attempting to maintain a monopoly at the expense of patients.
October 24, 2024
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