Rebekah Moan

Colorectal Cancer
No advantage for ctDNA assay for monitoring colorectal cancer
A research team led by Dr. Marwan Fakih at the City of Hope Comprehensive Cancer Center in Duarte, CA, sought to determine which technique is superior in identifying residual disease and early cancer recurrence: Natera's Signatera ctDNA assay or CT scans and a CEA blood draw. They found the National Comprehensive Cancer Network's (NCCN) current standard of care (CT scans and a CEA blood draw) had higher sensitivity than the assay (JAMA Network Open, March 8, 2022, Vol. 5:3, e221093).
March 9, 2022
2022 03 10 00 18 3072 2022 03 10 Ct Dna Fakih Marwan 400 20220310005244
Sequencing
Whole-genome sequencing aids diagnosis of rare diseases
In a pilot study, the genes of nearly 5,000 people with rare, undiagnosed diseases were analyzed by researchers from Genomics England and Queen Mary University of London partnered with the National Institute for Health Research BioResource. The group claimed the project was the first to analyze the diagnostic and clinical effect of whole-genome sequencing for a wide range of rare diseases within a national healthcare system -- in this instance, the U.K. National Health Service (NHS).
November 10, 2021
2021 11 10 18 26 8156 Science Genome Sequence Dna Map 400
Pathology, histology
New pathology group tackles lab medicine's economic issues
The nonprofit think tank, which was founded in 2019 but didn't begin operations until earlier this year, seeks to consider the "challenges and issues faced by people in the pathology and lab services industry, while at the same time trying to come up with practical solutions," said Allegra Klein, PNPL's director.
November 8, 2021
2019 11 15 22 54 6305 Business Hands 400
Tuberculosis
How pathologists act as 'firefighters' during COVID-19
Especially in the early stages of the pandemic, there were numerous unknowns about how to proceed with autopsies because COVID-19 was an unknown disease. What type of infectious disease was it? Was it like tuberculosis, HIV, hepatitis C, or mad cow disease?
October 3, 2021
2021 04 27 15 25 5437 Pathology Digital Workstation Microscope 400
COVID-19
FDA warns labs that SARS-CoV-2 variant could cause false-negative test results
The FDA said it is monitoring an emerging variant of the SARS-CoV-2 virus from the U.K. known as the B.1.1.7 variant. The B.1.1.7 variant is associated with an increased risk of transmission of COVID-19, so early identification of the variant may help reduce further spread of infection.
January 7, 2021
2019 02 13 19 24 5396 Fda Logo V2 400
Moderate Complexity Test
CMS to cut COVID-19 payments to slower labs
Under the new policy, labs that take longer than two days to complete COVID-19 tests will be paid $75 -- a 25% pay cut.
October 15, 2020
2020 10 16 22 39 6807 Dollar Money Coronavirus Mask 400
Moderate Complexity Test
AACC: LDTs play crucial role in patient care
Furthermore, adding regulation by the U.S. Food and Drug Administration (FDA) would be duplicative, burdensome, and could stymie the ability of labs to respond quickly to new diseases like COVID-19.
October 15, 2020
2020 02 13 23 04 0191 Lab Scientists 400
Payor Coverage
Clinical labs face interruptions, staffing shortages
The 100-question survey assessed several aspects of testing SARS-CoV-2: sample types, patient populations, methodologies, validation, performance, supply chain, public health reporting, laboratory workforce, and reimbursement. The survey responses came from 113 representatives affiliated with U.S.-based academic medical centers, commercial reference laboratories, public health laboratories, and community hospitals.
October 8, 2020
2020 02 25 23 24 4831 Lab Microscope Woman 400
Point-of-Care Testing
Point-of-care testing leads South Korea's response to COVID-19
South Korea's response to the COVID-19 pandemic has been widely lauded -- and is becoming heavily studied. The country was one of the earliest countries to see cases appear after the novel coronavirus outbreak began in Wuhan, China, but was still able to control the spread of the virus better than other countries that had more time to prepare.
August 23, 2020
2020 01 27 21 38 4451 Lab 2019 Coronavirus Test 400
Fibrosis
FIB-4 blood biomarker predicts risk of developing severe liver disease
The research team led by Dr. Hannes Hagstrom, a hepatologist at the Karolinska University Hospital and docent at Karolinska Institutet in Sweden, calculated FIB-4 at two time points within five years to determine whether doing so could predict the risk of cirrhosis. They found yes, it could: An increase of one unit in FIB-4 boosted the risk of severe liver disease (adjusted hazard ratio (aHR)=1.81, 95% confidence interval (CI) = 1.67-1.96).
July 6, 2020
2019 08 20 22 16 4501 Liver Anatomy 400
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Validation
Immunovia announces positive results for next-gen pancreatic cancer test
Diagnostics company Immunovia announced positive results for the newest generation of its pancreatic cancer test from a model-development study, announcing that the test achieved both its primary and secondary endpoints.
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Collaboration
Vertex to pay $25M upfront to scale cell manufacturing technology
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Bristol Myers Squibb to reduce workforce in restructuring plan
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U.K. Patents Court rules Bio-Techne patents invalid in infringement lawsuit
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Immunovia announces positive results for next-gen pancreatic cancer test
By LabPulse.com staff writers
Diagnostics company Immunovia announced positive results for the newest generation of its pancreatic cancer test from a model-development study, announcing that the test achieved both its primary and secondary endpoints.
April 25, 2024
Pancreas New Social
Vertex to pay $25M upfront to scale cell manufacturing technology
By LabPulse.com staff writers
As part of the deal, Vertex was also willing to pay up to $215 million in milestones achieved in connection with the development of a scaled-up process for fully differentiated islet cells.
April 25, 2024
Research Money Social
Bristol Myers Squibb to reduce workforce in restructuring plan
By LabPulse.com staff writers
As part of a restructuring plan intended to cut $1.5 billion in costs, Bristol Myers Squibb plans to cut about 6% of its workforce, according to the firm.
April 25, 2024
Business Financial Results Social
U.K. Patents Court rules Bio-Techne patents invalid in infringement lawsuit
By LabPulse.com staff writers
The Patents Court of the High Court of England and Wales has ruled that two patents owned by Bio-Techne are invalid, rejecting a patent infringement lawsuit filed by Bio-Techne/ACD in the U.K. against Molecular Instruments.
April 24, 2024
Law Books Social
Scout secures CARB-X grant to advance diagnostic test development
By LabPulse.com staff writers
Scout, formerly Uh Oh Labs, will advance its point-of-care (POC) diagnostic test for sexually transmitted infections (STIs) with a new $1 million accelerator grant.
April 22, 2024
Credit: National Institute of Allergy and Infectious Diseases (NIAID)
Mission Bio launches new features for Tapestri platform
By Matt Limb
Mission Bio has launched new multiplexing features for its Tapestri platform, saying they will make single-cell technology more affordable and accessible to the biomedical community.
April 24, 2024
Test Tubes Social
Quest adds new biomarker test to Alzheimer's portfolio
By LabPulse.com staff writers
Quest Diagnostics has launched a new blood biomarker test as part of its AD-Detect portfolio of blood tests for Alzheimer's disease risk assessment.
April 23, 2024
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Bio-Techne files EU patent infringement suit against Molecular Instruments
By LabPulse.com staff writers
Life sciences company Bio-Techne has filed a lawsuit against Molecular Instruments in the pan-European Unified Patent Court, alleging patent infringement of its RNAscope in situ hybridization technology.
April 23, 2024
Legal Scales Social
Target ALS launches new data portal for research
By Matt Limb
A nonprofit medical research foundation has launched a data portal designed to help spur scientific breakthroughs for the disease amyotrophic lateral sclerosis (ALS).
April 23, 2024
Dna Data Ai Social
Ipsen, Skyhawk to collaborate on drug discovery for rare neurological disorders
By LabPulse.com staff writers
Biopharmaceutical company Ipsen and clinical-stage biopharmaceutical firm Skyhawk have signed an exclusive collaboration to discover and develop small-molecule therapeutics targeting RNA to treat rare neurological disorders.
April 22, 2024
Nerve Neuron Axon Social
Engineered Cas clears barrier to antiviral CRISPR therapies
By Nick Paul Taylor
Researchers have engineered a Cas enzyme to enhance activity against RNA viruses, resulting in a system that completely blocked the replication of various SARS-CoV-2 strains.
April 19, 2024
Researcher
AI-powered endoscope doubles detection of high-risk esophageal lesions
By Nick Paul Taylor
Deep learning has doubled the detection of high-risk lesions during routine endoscopies in a clinical trial of more than 3,000 patients in China.
April 17, 2024
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