NCCN revamps guidelines on colon cancer genetic testing

By staff writers

July 24, 2020 -- The U.S. National Comprehensive Cancer Network (NCCN) has revamped its guidelines on screening for familial/inherited conditions associated with colorectal cancer, notably Lynch syndrome.

The NCCN published its "Genetic/Familial High-Risk Assessment: Colorectal" oncology clinical practice guidelines on July 21, in a move the organization said was aimed at making the guidance reflective of new technologies and more intuitive for healthcare providers. Guidelines are available with free registration on the NCCN website.

The changes include the following:

  • Updated Lynch syndrome section; management recommendations are now separated out according to major causative gene mutations
  • Updated principles of testing in the Lynch syndrome section highlighting the use of polymerase chain reaction and next-generation sequencing technology to detect microsatellite instability
  • Expanded surveillance/management recommendations for individuals with Lynch syndrome after colonoscopy, and for those who have a family history of colonic adenomatous polyposis of unknown etiology
Mailing FIT kits to Medicaid patients could boost colon cancer screening rates
Mailing fecal immunochemical test (FIT) kits to U.S. Medicaid patients could increase the rate of colon cancer screening and appears to be cost-effective,...
Broad genetic testing spots inherited mutations in young cancer patients
Younger adult cancer patients with tumors that more typically strike later in life may benefit from genetic testing to pick up on germline mutations,...
Study urges broader genetic testing of breast cancer patients
Women 65 and younger with a breast cancer diagnosis should be offered genetic testing to determine if they are at risk for additional cancers, according...
USPSTF calls for more BRCA1/2 genetic screening, testing
Broader recommendations on screening for BRCA1/2 genetic mutations published by the U.S. Preventive Services Task Force (USPSTF) on August 20 represent...

Copyright © 2020

Last Updated ls 7/23/2020 4:03:39 PM

Register below for our weekly Letter from the Editor to receive the latest Clinical Lab news and insights.