Cases
Man in his 60s with a bladder mass   

Additional questions

What is the most frequent age at presentation of RMS?
Young children <3 years old
Elderly individuals
Patients in their early to mid-teens
Women of middle age

Which immunostaining is useful for the diagnosis of the alveolar subtype of rhabdomyosarcoma?
ALK
Desmin
MyoD1
Myogenin
Smooth muscle actin

What are the two associated fusion proteins in alveolar rhabdomyosarcoma (ARMS)?
20% of cases are positive for PAX3-FOXO1 fusion gene, 60% for PAX7-FOXO1 fusion gene
60% of cases are positive for PAX3-FOXO1 fusion gene, 20% for PAX7-FOXO1 fusion gene
Most ARMS cases are fusion-negative
No specific fusion for ARMS has been reported

What is the prognosis for RMS of the bladder?
ARMS has a poorer prognosis than the embryonal subtype
Staging is predictive of outcome
ARMS with PAX3-FOXO1 fusion often has a poorer outcome when metastasized
Dependent on factors including site and tumor size, invasion extent, distal lymph node involvement, and distant metastases
All of the above