Cases
Man in his late forties with left renal mass    

Findings and diagnosis

Findings

  • IHC: Stained positive for vimentin, CAIX, CK7 (focal), CD10, desmin (highlights muscle in stroma). Negative AMACR.
  • Molecular testing: FISH study performed; the study showed no loss of Chr 3p, which confirms that this is not the clear cell subtype.

Differential diagnosis

  • Renal angiomyoadenomatous tumor
  • Clear cell papillary renal cell carcinoma
  • Renal cell carcinoma with leiomyomatous stroma
  • Papillary renal cell carcinoma

Diagnosis: Renal cell carcinoma with leiomyomatous stroma