60-year-old man with sudden weight loss
History and images
Our appreciation is extended to Dr. Abdul Abid, University of Texas Medical Branch, for contributing this case.
History: A 60-year-old man presented with sudden weight loss and hematuria. An ultrasound of the abdomen and pelvis revealed a right-sided kidney mass. A subsequent magnetic resonance imaging (MRI) exam demonstrated a heterogeneously enhancing mass arising from the mid/upper pole measuring 12 cm in the greatest dimension. A nephrectomy was performed. Gross and microscopic images are presented.
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Microphthalmia transcription factor (MiTF) translocation renal cell carcinoma
Clear cell carcinoma with eosinophilic features
Low-grade oncocytic tumor
Chromophobe renal cell carcinoma
Cytokeratin 7 (CK 7), cluster of differentiation 10 (CD10), and transcription factor (TFE)
CK 7, CD117, and E-cadherin
Paired box gene 8 (PAX8), carbonic anhydrase IX (CA-IX), and CD10
PAX8, CA-IX, and alpha methyacyl CoA racemase (AMACR)