Research & Development
Inflammation: Page 3
Inflammatory marker sCD14 lurks in dementia
Earlier detection of dementia using convenient blood tests is an important goal for Alzheimer's disease and other dementia disorders so that patients can be identified in time to be included in clinical trials and hopefully treated successfully. Inflammation and infection have become intriguing areas of research in Alzheimer's disease.
December 10, 2019
Low white blood cell count warns of bad outcomes
The retrospective study analyzed data collected by the U.S. Centers for Disease Control and Prevention (CDC) for a sample of 31,178 generally low-risk outpatients enrolled in the National Health and Nutrition Examination Survey (NHANES). The researchers evaluated the associations between lymphopenia; other immunohematologic (IH) abnormalities, i.e., elevation of the inflammation biomarker C-reactive protein (CRP) and abnormal red blood cell distribution width (RDW); and survival, adjusting for clinical variables.
December 2, 2019
Lab tests show vitamin D, omega-3 fish oil miss health markers
The incorporation of VITAL findings into guidelines and practice is partly dependent on results from several ancillary trials testing supplementation in different patient populations.
November 11, 2019
AI algorithm can accurately diagnose appendicitis
A team of researchers led by Josephine Reissmann of Charité Universitätsmedizin Berlin trained an AI algorithm to provide an automated diagnosis of appendicitis based on the analysis of full blood counts, C-reactive protein (CRP), and appendiceal diameters on ultrasound examinations. In testing, the algorithm was 90% accurate for diagnosing appendicitis.
October 1, 2019
Inflammation marker in blood linked to early death in army recruits
There was a significant association between erythrocyte sedimentation rate (ESR) and overall mortality, cardiovascular death, and cancer mortality decades later in the study of 106,120 male recruits, according to registry data spanning approximately 30 years in Sweden, reported Elizabeth Kantor, PhD, an epidemiologist at Memorial Sloan Kettering Cancer Center, and colleagues in a research letter.
September 3, 2019
Intriguing results for inflammation blood test | Dollars and sense on tests | USPSTF's new stance on hepatitis C screening
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September 2, 2019
NIH-funded studies aim to get to the bottom of depression, suicide
The NIMH has jointly awarded a $3.6 million grant to investigate the potential for a blood test for suicide risk to researchers at the Van Andel Institute in Grand Rapids, MI; Pine Rest Christian Mental Health Services, also of Grand Rapids; and Columbia University in New York City. The grant money will be used over five years to study inflammatory mechanisms associated with suicide risk, based on research by Dr. Lena Brundin, PhD (Van Andel); Dr. Eric Achtyes (Pine Rest); and Dr. J. John Mann (Columbia).
August 28, 2019
Microfluidic device could enable faster sepsis diagnosis
Sepsis occurs when the body's immune response to an infection spurs a chain reaction of inflammation. Sepsis is a leading cause of death in hospitals in the U.S., resulting in nearly 250,000 patient deaths a year.
July 23, 2019
Study shows baby steps toward liquid biopsy for pediatric fatty liver disease
A group affiliated with the multicenter European Paediatric Non-Alcoholic Fatty Liver Disease Registry (EU-PNAFLD) showed the association of certain fats in the blood with fatty liver on liver biopsies in a poster presentation of 67 patients at the meeting, which was held June 5 to 8 in Glasgow, Scotland. This shows potential for developing a commercial test for the presence of nonalcoholic steatohepatitis (inflammation) and fibrosis (scarring) as an alternative to an invasive liver biopsy within five years, the researchers concluded.
June 9, 2019
NIH study finds vaginal bacteria could predict preterm births
A research group led by Jennifer Fettweis, PhD, of Virginia Commonwealth University analyzed data from a subpopulation of over 1,500 women who participated in the NIH Common Fund's Human Microbiome Project. The researchers collected samples of vaginal bacteria from 45 pregnant women who delivered their babies preterm and compared them with samples from 90 women who delivered at full term. Almost 80% of the 135 women were African American.
May 29, 2019
Single-cell sequencing supplies clues about managing lupus
The study of tissue samples from renal biopsies of 21 patients, with skin punch biopsy specimens also available for 17 patients, showed that interferon (IFN) response scores as assessed with single-cell sequencing technology were elevated in tubular cells and keratinocytes from patients with lupus nephritis (LN), compared with healthy controls. Lupus nephritis is a common and debilitating condition involving kidney inflammation in patients with systemic lupus erythematosus (SLE).
May 20, 2019
Failed study leaves CRP test hanging as biomarker in bipolar depression
The results leave the potential role of CRP as a biomarker up in the air. They also highlight the broader challenges in developing biomarkers and personalized treatments in the field of psychiatry.
May 7, 2019
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