Research & Development
Inflammation: Page 2
COVID-19 patients at risk for heart complications
The study findings suggest yet another facet of the illness that must be tracked, wrote a team led by Dr. Valentina Puntmann, PhD, of University Hospital Frankfurt in Germany.
July 27, 2020
CRP test guides steroid Rx for coronavirus, could help save lives
As an indicator of inflammation, CRP has been used in many different clinical scenarios, though its nonspecific nature is a downside. In this observational study, which was conducted at the Albert Einstein College of Medicine in the Bronx, New York, researchers analyzed efficacy and safety of systemic treatment with glucocorticoids -- an emerging and promising treatment option for coronavirus -- and how outcomes were associated with levels of CRP. Steroids are widely available as is the CRP lab test, they noted.
July 21, 2020
Procalcitonin test signals infection in heart attack patients
As an important marker for inflammation in the body, a blood test for PCT is useful for systemic bacterial infections and sepsis. But its value for detecting infection in patients with acute ST-elevation myocardial infarction (STEMI) -- an area of unmet need -- has been unclear. One key question is whether it is specific enough for infection, or whether levels would increase due to cardiac injury -- a limitation of other inflammatory biomarkers such as C-reactive protein (CRP) and white blood cell counts.
June 15, 2020
Interleukin-6 testing grows rapidly, with limited evidence of utility
Cytokines are small proteins released by many different types of cells, including the white blood cells of the immune system. Cytokines help regulate the immune system's response to an infection and cause inflammation. The storm happens when the release of cytokines goes into an uncontrolled overdrive causing hyperinflammation which damages the body's organs. In the lungs, this inflammation causes fluid to accumulate in the airspaces which then leads to ARDS.
June 8, 2020
AI-driven app uses blood biomarkers to flag high-risk COVID-19 patients
The app's development was led by researchers at the NYU College of Dentistry, who used data from 160 patients in Wuhan, China to identify four biomarkers in blood tests that were significantly elevated in patients who died from the novel coronavirus:
June 2, 2020
Pathologists document placenta damage in moms with SARS-CoV-2
The study examined placentas from 16 pregnant patients. Results were published by Dr. Jeffrey Goldstein, assistant professor of pathology at Northwestern University Feinberg School of Medicine, and colleagues. Placentas from 15 patients who delivered in the third trimester were compared to controls and found that decidual arteriopathy, a feature of maternal vascular malperfusion (MVM), was more prevalent, the authors reported.
May 26, 2020
FDA issues EUA for remdesivir to treat severe COVID-19 cases
The emergency authorization allows for remdesivir to be distributed in the U.S. and administered intravenously by healthcare providers to treat suspected or confirmed severe COVID-19 cases, according to the agency. Severe cases are defined as patients with low blood oxygen levels or needing oxygen therapy or more intensive breathing support.
May 3, 2020
Pathologists advance understanding of deadly female genital tract infections
Group A strep is typically found in the mouth, but it can also infect other mucosal areas of the body, with deadly results. The researchers noted that GAS surface proteins cause an estimated 700 million human infections annually around the world, including 15 million in the U.S. GAS is at the root of puerperal sepsis (also known as childbed fever), which is the leading cause of maternal deaths, and it causes necrotizing myometritis (inflammation of the uterine myometrium) as well as severe infections in newborns.
March 18, 2020
Study identifies risk factors for death from coronavirus
In the observational study, Dr. Bin Cao of Capital Medical University and colleagues from China examined the data of 191 patients with confirmed COVID-19 at two different hospitals. The median age of the patients was 56 and nearly 30% died in the hospitals. They also had various comorbidities, the most common being hypertension (30% of patients), diabetes (19%), and coronary artery disease (8%).
March 10, 2020
Sphingotec's POC penKid blood test flags kidney injury
The study evaluated the diagnostic in combination with serum creatinine and estimated glomerular filtration rate (eGFR), an established marker of kidney function. Elevated results on penKid considered with eGFR results correlated with outcomes, according to the Hennigsdorf, Germany-based company. High penKid plasma levels identified all ED patients with hidden acute injury and acute kidney injury at the time of admission and reflected worsening of kidney function, the company explained.
December 22, 2019
Blood tests chart heart damage from booze
Researchers evaluated blood sample test results for 2,479 adults in the city of Arkhangelsk, Russia, who were enrolled in the Know Your Heart general population study. They also examined samples from 278 patients who were being treated for alcoholism at the Arkhangelsk Regional Psychiatric Hospital.
December 18, 2019
Inflammatory marker sCD14 lurks in dementia
Earlier detection of dementia using convenient blood tests is an important goal for Alzheimer's disease and other dementia disorders so that patients can be identified in time to be included in clinical trials and hopefully treated successfully. Inflammation and infection have become intriguing areas of research in Alzheimer's disease.
December 10, 2019
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