Alzheimer's: Page 4

Diadem nabs $2.5M to further validate Alzheimer’s blood test
The two-year grant will enable Diadem, a company that has been developing a blood-based test for the early prediction of Alzheimer's disease (AD), to leverage data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), a longitudinal multicenter study designed to enable development of biomarkers for the early detection and tracking of AD.
September 6, 2022
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Roche nabs FDA breakthrough designation for Alzheimer’s Dx
The panel, a blood-based biomarker test, is intended to be used in conjunction with other clinical information in symptomatic patients who are being evaluated for Alzheimer's disease and other causes of cognitive decline.
July 18, 2022
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Alzheimer’s test developer Diadem joins DPUK
Diadem's AlzoSure Predict blood test identifies signs of cognitive impairment that will or will not progress to Alzheimer's dementia up to six years before diagnosis.
June 12, 2022
2020 03 31 23 03 5810 Brain Dementia Leaves 400
Diadem highlights new study on AlzoSure test for Alzheimer's
In a retrospective study published online May 17 in the Journal of Prevention of Alzheimer's Disease, researchers reported that AlzoSure Predict achieved an area under the curve (AUC) of more than 0.98 for identifying people who would progress to future symptomatic Alzheimer's disease up to six years before diagnosis.
May 17, 2022
2019 07 15 19 08 6013 Amyloid Plaque Alzheimer 400
New biomarker could detect early Alzheimer’s before symptoms
In addition, the findings have some implications for taking brain-boosting dietary supplements that contain the amino acid serine. The key compound responsible for producing serine in the body is PHGDH. The scientists reported that PHGDH mRNA and protein levels had increased in the brains of two mouse models of Alzheimer's disease or tauopathy.
May 4, 2022
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FDA grants approval for Fujirebio assay for Alzheimer's plaques
The FDA granted clearance under its breakthrough device pathway to Fujirebio's Lumipulse G β-Amyloid Ratio (1-42/1-40) test, which is designed to measure the ratio of β-amyloid 1-42 and β-amyloid 1-40. These are proteins that can accumulate and form plaques in the brain; concentrations of these proteins can be detected in cerebral spinal fluid (CSF).
May 3, 2022
2022 05 04 20 54 3251 Computer Brain Hemisphere 400
Quest publishes Alzheimer’s report, unveils blood test
The report, called "The Coming Alzheimer's Disease Healthcare Revolution: U.S. Physician and Adult Perspectives on the Future of Diagnostics and Treatment," found that 66% of physicians believe that "we are on the precipice of groundbreaking new treatment options" for Alzheimer's disease, according to Quest.
May 3, 2022
2019 07 15 19 08 6013 Amyloid Plaque Alzheimer 400
Does race affect interpretation of Alzheimer's disease tests?
An international team led by researchers at Washington University School of Medicine in St. Louis, MO, compared three experimental blood tests and a commercially available Alzheimer's disease test they developed in previous work (PrecivityAD, C2N Diagnostics) in 76 pairs of Black and non-Hispanic white participants.
April 21, 2022
2022 03 01 23 02 5066 Older Woman Anxious 400
Quanterix partners with Alzheimer's research foundation
As part of the partnership, the ADDF will fund a series of prospective clinical trials to validate the test in collaboration with Amsterdam University Medical Centers in the Netherlands. The research will be coordinated through Quanterix's Simoa Accelerator Services Lab, which provides contract research services and clinical sample testing.
March 30, 2022
2019 04 30 23 29 0302 Brain 400
Sysmex, Eisai tout Alzheimer's research at AD/PD 2022
As part of a nonexclusive agreement to create diagnostic agents for dementia, researchers from the companies compared the performance of the plasma beta-amyloid ratio measured using the Sysmex HISCL automated immunoassay system with that of amyloid status on positron emission tomography (PET) imaging as determined by the Centiloid method. Their technique was assessed in a discovery study in 180 patients and in a validation study involving 191 patients who were clinically diagnosed with mild Alzheimer's disease or mild cognitive impairment.
March 22, 2022
2019 07 15 19 08 6013 Amyloid Plaque Alzheimer 400
Spinal fluid tests may aid PET scans of Alzheimer's disease
A Swiss group led by senior author Michael Schöll, PhD, of the University Gothenburg investigated whether fluid and blood biomarkers that indicate Alzheimer's disease could predict the accumulation of neurofibrillary tau tangles seen on PET scans in patients diagnosed with the disease. They found the lab tests performed well enough to help select patients for PET imaging studies evaluating new treatments.Associations of baseline beta-amyloid PET and baseline phosphorylated tau-181 (p-tau181) with F-18 flortaucipir (FTP) Standardized uptake value ratio (SUVR) annualized change for (A) cognitively unimpaired and (B) cognitively impaired individuals. Image courtesy of Alzheimer's & Dementia: The Journal of the Alzheimer's Association.Associations of baseline beta-amyloid PET and baseline phosphorylated tau-181 (p-tau181) with F-18 flortaucipir (FTP) Standardized uptake value ratio (SUVR) annualized change for (A) cognitively unimpaired and (B) cognitively impaired individuals. Brain surface renderings depict Pearson correlation coefficients adjusted for age and sex (r) representing the strength of the association between the different biomarkers and F-18 flortaucipir SUVR change in each brain region. The right upper panel represents age- and sex-adjusted Pearson correlation coefficients (r), along with p-values, for the association between the biomarkers and F-18 flortaucipir SUVR change in the Alzheimer's disease meta-region of interest (ROI). The root mean squared error (RMSE) for the prediction of F-18 flortaucipir SUVR change by a linear model with the biomarker as predictor and age and sex as covariates. RMSE was estimated using leave-one-out cross-validation. Voxel-wise statistical maps were thresholded using more lenient cluster-forming thresholds of p < 0.05 (uncorrected) at the voxel level and further thresholded at the cluster level by restricting results to clusters with a number of voxels higher than the expected number of voxels as predicted using random field theory. Image courtesy of Alzheimer's & Dementia: The Journal of the Alzheimer's Association.
March 3, 2022
2022 03 02 20 27 6315 2022 03 04 Tau Biomarkers 400
AltPep secures FDA breakthrough device designation
Soba-AD is designed to selectively detect toxic oligomers that trigger events associated with Alzheimer's disease such as cognitive impairment and neurodegeneration, according to the company. The goal is to detect the early molecular triggers of the disease before plaque formation, AltPep Founder and CEO Valerie Daggett, PhD, said.
March 1, 2022
2019 05 13 16 12 9218 Lab Blood Woman2 400
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