Cervical Precancer

Mailed HPV home test kits doubled cervical cancer screening rates in study

By Elissa Wolfson

Mailing human papillomavirus (HPV) self-collection kits for at-home use improved cervical cancer screening in under-screened, low-income women by nearly two-fold.

May 12, 2023

HPV, Pap cotesting best for cervical cancer detection in Quest study

By Melissa Busch, LabPulse.com assistant editor; Emily Hayes, editor in chief

Cotesting involves Pap and HPV screening using the same specimen. A new study of women 30 years or older by researchers at Quest Diagnostics and the University of Pittsburgh Medical Center found that cotesting outperformed HPV or Pap testing alone for detecting precancer or cancer. In the retrospective study, the researchers evaluated deidentified results for tests conducted between 2010 and 2018 by Quest in 13.6 million women; 8,059 had precancers and 1,259 were subsequently diagnosed with cervical cancer.

July 8, 2020

Machine learning could 'transform' cervical cancer screening, NCI researchers report

By Emily Hayes

The NCI researchers described positive experiences with Cytoreader, an automated system for evaluating digital dual-stained whole-slide images for the protein biomarkers p16 and Ki-67, using data from three epidemiology studies of patients with cervical and anal cancers who were positive for human papillomavirus (HPV). The automated system assesses the number of dual-stained positive cells and flags the ones that exceed predefined cutoff points.

June 25, 2020

Becton Dickinson files for Onclarity FDA approval in 11 more HPV types

By LabPulse.com staff writers

The Onclarity test is currently approved for detecting the three HPV genotypes -- 16, 18, and 45 -- that cause most cases of cervical cancer and precancer. However, the test detects 14 high-risk forms of HPV, according to Becton Dickinson, and the PMA filing seeks approval for 11 additional types, including types 31, 51, and 52. In a statement, the company explained that while HPV types 16, 18, and 45 have traditionally caused most cases of cervical cancer, they are becoming less common due to HPV vaccination in younger populations.

November 13, 2019