Broad genetic testing spots inherited mutations in young cancer patients

2020 01 14 22 12 7635 Dna Sequencing2 400

Younger adult cancer patients with tumors that more typically strike later in life may benefit from genetic testing to pick up on germline mutations, according to a study presented at the American Association for Cancer Research (AACR) virtual meeting, held June 22 to 24.

The study evaluated broad-panel genetic blood testing in 1,201 patients between the ages of 18 and 39 who had undergone next-generation sequencing and were treated at Memorial Sloan-Kettering Cancer Research Center. Of the total, 877 had early-onset cancer -- that is, they had tumor types that would normally occur later in life, such as in the breast and colon.

The study was one of five that were highlighted in an AACR press briefing on June 19 ahead of the meeting.

Per the Memorial Sloan-Kettering testing protocol for cancer, patients' blood samples were screened for 88 genes. In the 877 individuals with early-onset cancer, 21% had an inherited genetic mutation, most typically for cancers of the breast, pancreas, or kidney. The most common mutations detected were the following:

  • BRCA1
  • BRCA2
  • ATM
  • CHEK2
  • Lynch syndrome genes

For the 324 patients determined to have cancers that are more typically found in younger patients, such as sarcomas, 13% had an inherited mutation, and germline TP53 mutations were most common, the researchers reported.

Those with a number of the early-onset types of cancer have diseases that could be screened for and potentially treated with a targeted drug. For example, BRCA-mutated disease may be targeted with poly (ADP-ribose) polymerase (PARP) inhibitors, which are now approved not only for the first indication of ovarian cancer but also for mutated pancreatic cancer and, most recently, mutated prostate cancer.

The results show that from a genetic perspective, early-onset cancers are heterogenous and are associated with a much higher prevalence of germline mutations compared with other tumor types in younger patients, Dr. Zsofia Stadler, a medical oncologist at Memorial Sloan-Kettering, said during the AACR press briefing.

Researchers are now looking to determine if there is a family history in the patients who tested positive for inherited mutations to further decipher their risk profiles. Another area of follow-up research is to determine whether the germline mutations that were identified are the main drivers of the patients' diseases.

Bigger isn't always better

In an interview after the briefing, Stadler acknowledged issues associated with testing for such an expansive set of genes. Large-panel testing is sometimes criticized for identifying variants of unknown or uncertain significance (VUS), that is, indeterminate findings, which can result in unnecessary follow-ups and prophylactic treatments.

"A finding of a VUS is very frustrating for the patient and for us," Stadler said. "Does that variant actually cause cancer or is it just a normal benign germline variant that doesn't do anything?"

A disease-specific panel is more typical in a clinical scenario, but a broad panel is appropriate for research purposes; in this study, testing was conducted in patients who had not met criteria generally used to steer patients to genetic testing.

Providers need to be cognizant that bigger is not always better -- but it is more complex, Stadler said. On the flipside, the bigger the panel, the more often you may identify a finding that you are not necessarily looking for, such as a mutation that predisposes a breast cancer patient for a cancer in the colon, she added. And in that scenario, the patient could undergo closer surveillance for a second cancer type.

Pushing broad-panel testing from the research to the clinical setting for a group like early-onset cancer patients might make sense, with care during patient counseling regarding incidental findings or variants of uncertain significance, the clinician said.

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